Alkali compounds of dioxydiaminoarsenobenzene.



PAUL EHRLIOH AND ALFRED BERTHEIM, OF FRANKIORT-ON-THE-M-AIN, GERMANY,

ASSIGNOBS TO FARIBWERKE VORM. MEISTER; LUCIUS & ,BRUNING. 0F HOCHST-ON- THE-MAIN, GERMANY, A. CORPORATION OF GERMANY.

ALKALI COMPOUNDS OF DIOXYDIAMINOARSENOBENZENE.

aoaaasa. No Drawing.

Specification of Letters Patent. A

Patented a t. as; rare.

To all whom it may concern Be it known that we, PAUL EHRLICH, M. D., professor of medicine, and Ammo Burr- HEIM, Ph. D., chemist, citizens of the Empire of Germany, residingat Frankfort-onthe-Main, Germany, have invented certain new and useful 1m rovements in Alkali @ompounds' of Dioxy iaminoarsenobenzene, of which the following is a specification.

We have found that compounds of the dioxydiaminoarsenobenzene of great therawherein Me stands for an alkali metal. By the fact that these new compounds are soluble in water they are distinguished from the dioxydiaminoarsenobenzene, which is insoluble in water, whereas they differ from the dichlorhydrate of the latter compound,-which when dissolved in water shows an acid reaction, by the alkaline reaction of their solution. There are also difierences between-the various compounds as regards their points of fusion and decomposition respectively, although these points are not sharply defined. It is advantageous to produce the new compounds by treating the" alcoholic suspension of the base with alcoholates or with solutions of alkali-hydroxids or alkali-carbonates'. v

The following examples serve to illustrate our invention. Y

Example I: 73 grams of dioxydiaminoarsenobenzene are suspended in 700 com. of methyl alcohol and there' are then added, without access of air, 190 grams of a 5% solution of sodium methylate. The mixture is stirred until' it is dissolved, then filtered in hydrogen or nitrogen atmosphere in order to avoid oxidation, whereupon the solution. is-run, without access of oxygen, into a mixture of 1 liter of absolute alcohol and 4 liters of ether, while quickly stirring. The precipitate thus obtained is filtered without access of air, washed with a mixture of equal parts of alcohol and ether and dried in a vacuum without access of air. Thus a powder of a yellow color with a green hue is obtained, which'is readily soluble in water and, whenexposed for a longer time to the air, loses its original solubility whereby it is distinguished, apart from the alkaline reaction it shows, from the dichlorhyd'rate of the dioxydiaminoarsenobenzene. Its formula is:

NHZ

foNa Example H: 36.6 grams of dioxydiaminoarsenobenzene are suspended in 120 gramsof methyl alcohol and there are then added' 11.2 grams of potassium hydroxid dissolved in 150 com. of methyl alcohol. The resulting clear solution is run at 5 G. into a mixture of 1 liter of alcohol and 3 liters of ether, whereupon the potassium salt separates in the form of a greenish-yellow powder readily soluble in water. In preparingthis compound, it is also necessary to prevent the access of oxygen, and the procedure for drying it is the same as that indicated in Example l. I

Having now described our invention, what we claim is: l

1. As new products, the alkali-diphenolates of the dioxydlaminoarsenobenzene, havipg the constitutional formula:

"wherein Me stands foran alkali metal,

being light-colored powders, readily solubeing a light colored powder, readily solu 10 ble in Water with alkaline reaction. ble in Water With alkaline reaction.

2. As a neW- product, the sodium-phenol- In testimony whereof, We afiix our sigateof the dioxydiaminoarsenobenzene, hav natures in'presence of two Witnesses. ing the constitutional formula: I PAUL EHRLICH;

NH2 NEE ALFRED BERTHEIM.

Witnesses: ELSE MEBUS, 

